Mngnoniim intracellular developed mole underground having regard to blind to survive under conditio

Space and Astronomy Astrophysics Astronomy Solar System space missions man in space environment and energy, Environmental Science Earth Science Environmental Issues Energy Transport computing and technology science and computing and robotics nano-tech military technology futurism Biology and Medicine evolution and nature of medical genetics Brain Society and History Science and Society History skeptic science fiction scientists scientific research and development in Israel having regard to Israel Israel Israel biotechnology space and defense industries Education Academy facebook twitter youtube rss
Latest Articles
Mngnoniim intracellular developed subterranean mole blind to survive under conditions of low oxygen levels (hypoxia) can help fight cancer, according to a study conducted jointly by the Institute of Evolution at Haifa University and the University of Illinois
Mngnoniim intracellular developed mole underground having regard to blind to survive under conditions of low oxygen levels (hypoxia) can help fight cancer, according to a study conducted jointly by the Institute of Evolution at Haifa University and the University of Illinois published in the FASEB and was funded having regard to by the Research Foundation Israel-United States (BSF ).
"Mechanisms developed by mole to survive under conditions of hypoxia similar mechanisms developed by cancer cells. If we can understand how to operate these mechanisms, allowing the rats to the underground to live his life 'normal', perhaps we can understand better how tumors destructive survive and evolve," said Professor Aaron Aviv, Haifa University, who conducted the study in collaboration with Dr. Mark Band from the University of Illinois.
Scientific attention to the uniqueness of the subterranean mole blind was drawn many years ago by Prof. Eviatar Nevo, founder of the Institute of Evolution at the University of Haifa. Subterranean mole adopted many skills that allow him to live in closed conduits underground, including having regard to the ability to live under conditions of oxygen deprivation, ability to survive in an environment of 3% oxygen (as opposed to 21% oxygen present in the air we breathe).
In recent years, scientists have focused their research through having regard to the isolation and characterization of genes that allow the operation the rats survive subsurface oxygen-door having regard to environment. having regard to So began this study, but as so often happens in science, the discovery of no less importance was discovered when researchers analyzed the results received.
The present study aimed to examine whether there are differences in the activity of the gene BNIP3 the subterranean mole rat and normal, above ground pool, entered a state of hypoxia. Results showed that the rats were introduced hypoxic stress is high expression of the gene, one of the functions to protect the body in a state of lack of oxygen. In contrast, the blind rats had little change in the expression of this gene. According to Prof. Avivi, One of a large number of tumors in humans is non-operation of the BNIP3 gene hypoxia conditions. That is, the activity pattern of molecular-genetic systems that allow some live "normal" underground rats resembles the activity of these tumors in humans.
"If we can understand the genetic mechanisms intermolecular allow rats underground to live his life, we may be able to contribute to understanding the mechanisms of survival of tumors, they are pathological and destructive so, hoping to find new ways and efficiency to fight the disease," said Prof. spring.
In addition to these findings similar findings having regard to were found by these researchers, for the expression of two other genes that function in rats and underground similarly tumors, and different from healthy tissue activity. One gene whose function is to encourage growth of new blood vessels ((VEGF and that "right" cell tumor receiving a constant supply having regard to of oxygen and survive, as the "right" to various tissues of the mole outstanding concentration of blood vessels significantly higher than, for example, in the rat, enabling them to deal with the lack of oxygen below the surface, and the second, having regard to the p53 gene, the output of visiting the activity of a large number of other genes - some working mechanism cell death, and some operating mechanisms of DNA repair. many cancers, as well as rat underground, and probably due to lack of oxygen, the gene encoding the p53 undergoes changes-structure followed by activating genes "facilities" much higher efficiency than the genes "Hmmitim".
Period of years it was a constant echoes my reaction to reading the articles are, at some point I stopped writing it because I felt I was repeating myself. You're right pedestal suppressor March 28th, 2009
Auditor Opinion